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CAS 9004-65-3 · E464 EINECS 618-389-1

HPMC Hidroxipropilmetilcelulose

Definition, Chemistry, and Industrial Role — a complete reference for formulators across construction, pharma, food, personal care, and industrial sectors.

HPMC is a water-soluble, non-ionic cellulose ether produced by chemically modifying natural cellulose derived from wood pulp or cotton linter. It delivers multiple functional benefits — water retention, thickening, film forming, binding, and workability improvement — within a single versatile ingredient.

~ Referência Rápida ~
Nome completo Hidroxipropilmetilcelulose
Número CAS 9004-65-3
Código Alimentício E464
Tipo iônico Não iônico
Solubilidade Cold water soluble
Pharma Name Hypromellose
Aparência Pó branco a esbranquiçado
Química
Cellulose ether chemistry lab
DS·MS Substitution
Análise de laboratório Chemical structure
What Is HPMC?

Definition, Chemistry,
e Industrial Role

HPMC is produced by reacting purified cellulose with methyl chloride and propylene oxide under controlled alkaline conditions. This process introduces two types of substituent groups onto the cellulose backbone, each influencing the final product's performance profile in different ways.

Methoxyl Groups (–OCH₃)

Control solubility, thermal gelation behavior, and surface activity of the cellulose ether.

Hydroxypropoxyl Groups

Influence water retention capacity, viscosity development, and compatibility with other ingredients.

The combination and ratio of these two substituents — expressed as degree of methyl substitution (DS) and molar substitution of hydroxypropyl (MS) — determine the grade's performance profile. Viscosity, measured at 2% aqueous solution using Brookfield or Ubbelohde methods, is the most commonly referenced parameter for grade selection, ranging from below 100 mPa·s to above 200,000 mPa·s depending on the grade.

Why HPMC Is Widely Used

HPMC is non-ionic — compatible with a wide range of additives, surfactants, salts, and pH conditions. It is also biodegradable, odorless, tasteless, and free from animal-derived raw materials, making it suitable for regulated and sensitive applications from drymix mortar to pharmaceutical excipients and food systems.

Dados Técnicos

HPMC Technical
Dados de Referência

The following table provides a general technical reference for Hydroxypropyl Methyl Cellulose. Exact values vary by product grade, viscosity level, substitution type, particle size, surface treatment, and testing method. This information is intended as a formulation reference starting point, not a final product specification.

ItemReferência Típica
Nome do produtoHidroxipropilmetilcelulose
AbreviaçãoHPMC
Número CAS9004-65-3
Código de Aditivo AlimentarE464
AparênciaPó branco a esbranquiçado
Tipo iônicoNão iônico
Base MolecularEter de celulose (celulose natural modificada)
Fonte da Matéria-PrimaPolpa de madeira ou linho de algodão
SolubilidadeSoluble in cold water; insoluble in hot water above gelation temperature; forms viscous solution
Gelificação térmicaGels upon heating; re-dissolves upon cooling (thermally reversible)
Faixa de ViscosidadeMultiple grades: low / medium / high / extra-high viscosity
Medida de ViscosidadeTypically at 2% aqueous solution (Brookfield or Ubbelohde)
Surface TreatmentTreated (delayed hydration) or untreated options available
Estabilidade do pHStable across approximately pH 3–11
Ionic CompatibilityCompatible with non-ionic, anionic, and many cationic systems
Funções principaisThickening, water retention, film forming, binding, workability, stabilization
Application SystemsDrymix, liquid, semi-solid, pharmaceutical, food, industrial
Documentos DisponíveisTDS, SDS, COA, recomendação de produto disponível mediante solicitação

Important: This table is a general reference only. For exact viscosity, pH, moisture content, ash content, particle size distribution, methoxyl content, hydroxypropoxyl content, and grade-specific values, please request the official TDS or COA from LANDERCOLL.

Notas
Referência de Grau

HPMC Product Grades —
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i.
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ii.
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iii.
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iv.
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v.
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Non-Surface-Treated

Faster viscosity development — quick hydration, suitable for fast-dissolving and direct-hydration formulations.

Note: Viscosity ranges listed above are approximate references. Actual LANDERCOLL HPMC grades should be selected according to your formulation, testing method, application environment, and required documentation. Contact our team for specific grade recommendations.

Funções principais

Key Functions of
HPMC in Formulation

HPMC is a multifunctional cellulose ether. In most applications, it contributes more than one functional benefit simultaneously. Below is a structured overview of its primary functions across different system types.

Retenção de água
i.
Retenção de água

In cement-based and gypsum-based systems, HPMC forms a polymer network that physically restricts water migration. Higher viscosity grades and higher dosage levels provide stronger water retention — preventing rapid water loss, incomplete hydration, and surface cracking.

Espessamento
ii.
Thickening & Viscosity Control

HPMC dissolves in cold water to form a viscous, pseudoplastic (shear-thinning) solution. Viscosity decreases under shear during mixing and recovers at rest — supporting both processability and in-place stability across drymix mortar, detergents, personal care, and coatings.

Capacidade de trabalho
iii.
Workability Improvement

In drymix construction materials, HPMC makes mortar smoother, more cohesive, and easier to spread, trowel, scrape, and finish. It is a combined result of water retention, viscosity building, and lubrication effects — particularly valued in tile adhesive, wall putty, and gypsum plaster.

iv.
Controle de Rheologia

Supports flow control, sag resistance, leveling behavior, and application stability. Prevents mortar from sliding on vertical surfaces, contributes to controlled flow in self-leveling compounds, and maintains stable viscosity in coatings and detergents.

v.
Formação de filmes

HPMC forms a continuous, flexible film after water evaporation — used in pharmaceutical tablet coating, edible film systems, construction surface integrity, and selected water-based coatings as a binder component.

vi.
Binding, Cohesion & Suspension

Supports structural integrity in tablet manufacturing, green strength in ceramics, and cohesion in drymix mortar. Also helps maintain uniform suspension of pigments, fillers, mineral powders, and active ingredients in coatings, detergents, and pharmaceutical systems.

Guia de Aplicação

HPMC Application
Guia de seleção

HPMC grade selection should always start from the application. A grade optimized for tile adhesive will not necessarily perform well in a detergent, personal care, or pharmaceutical system. The table below provides a structured reference for common application-to-grade matching.

AplicativoDireção de Grau RecomendadaPrincipais Requisitos de Desempenho
Adesivo para azulejosHigh to extra-high viscosityWater retention, open time, anti-slip, troweling feel
Massa para parede / revestimento de acabamentoMedium to high viscositySmooth scraping, water retention, surface finish
Reboco de cimento / gessoMedium to high viscosityWorkability, spreadability, water retention
GessoMedium to high viscositySmooth application, water management, consistency
Compostos de autonivelamentoLow to medium viscosityFlow control, stability, controlled water retention
Argamassa EIFS / ETICSAlta viscosidadeOpen time, anti-sag, adhesion-related support
Argamassa à prova d'águaMedium to high viscosityWorkability, uniform coating, stable consistency
Argamassa de alvenariaMedium to high viscosityWater retention, workability, bond support
Argamassa de ReparaçãoMedium to high viscosityAdhesion, workability, water retention
Detergente LíquidoViscosidade médiaTexture, viscosity, storage stability
Cuidados pessoaisLow to medium viscositySmooth texture, viscosity control, stability
Pharmaceutical ApplicationsSuitable pharmaceutical gradeFilm coating, binding, controlled release, excipient
Food ApplicationsSuitable food grade (E464)Thickening, stabilization, texture control
CerâmicaMedium to high viscosityBinding, green strength, suspension
Revestimentos à Base de ÁguaLow to medium viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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Guia de Dosagem

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por Aplicação

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Mortar application dosage
AplicativoDosagem de Referência Típica (% por peso)
Adesivo para azulejos0.2% – 0.5%
Massa para parede / revestimento de acabamento0.2% – 0.5%
Reboco de cimento / gesso0,15% – 0,4%
Gesso0.1% – 0.3%
Argamassa de alvenaria0.1% – 0.3%
Compostos de autonivelamentocURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Argamassa EIFS / ETICS0.2% – 0.5%
Argamassa à prova d'água0,15% – 0,4%
Argamassa de Reparação0,15% – 0,4%
Detergente Líquido0,2% – 1,0%
Cuidados pessoais0,1% – 1,0%
Revestimentos à Base de Água0,1% – 0,8%
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Aplicativos

Construção &Argamassa Drymix

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Adesivo para azulejos

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  • Adesivo para azulejos
  • Massa para parede e camada de acabamento
  • Reboco de cimento & gesso
  • Gesso
  • Compostos autonivelantes
  • Argamassa para EIFS / ETICS
  • Argamassa à prova d'água
  • Argamassa de alvenaria
  • Argamassa de reparo
  • Argamassa de isolamento
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  • Ready-mix dry mortar systems
Aplicativos

Home Care & Personal Care Fórmulas

Home care detergents Cuidados com o Lar & Detergentes

HPMC for Home Care
& Detergent Formulations

As a non-ionic polymer, HPMC is compatible with anionic and non-ionic surfactant systems commonly used in cleaning products. It builds smooth, stable viscosity that improves product appearance, pourability, and consumer perception — while helping maintain uniform suspension of insoluble components.

Aplicações Típicas

Laundry liquid Dishwashing liquid Toilet bowl cleaner Surface cleaner Gel cleaner Multi-purpose cleaner
  • Viscosidade controlada e corpo do produto
  • Stable texture and appearance over shelf life
  • Improved pourability and handling feel
  • Suspension support for insoluble components
  • Compatible with common surfactant systems
Personal care products Cuidados pessoais

HPMC for Personal
Care Formulations

In personal care systems, HPMC functions as a viscosity modifier, texture enhancer, and formulation stabilizer. It is water-soluble, non-ionic, and free from animal-derived raw materials — making it suitable for a wide range of rinse-off and leave-on products where smooth, consistent texture and formulation stability across temperature and storage conditions are required.

Aplicações Típicas

Shampoo & conditioner Hidratante corporal Removedor de maquiagem facial Hand soap Body lotion & cream Creme Dental Hair styling Intimate care
  • Smooth, uniform texture and sensory feel
  • Controlled viscosity across temperature ranges
  • Stable formulation structure over shelf life
  • Non-ionic — does not interfere with charged ingredients
Farmacêutico

HPMC for Pharmaceutical Applications

Suitable pharmaceutical grades of HPMC — referred to as Hypromellose in pharmacopoeial standards — are widely used as functional excipients in solid dosage forms, film coatings, and controlled-release systems. HPMC is recognized in the USP/NF, Ph. Eur., and JP pharmacopoeias.

Only grades manufactured and tested to pharmacopoeial standards should be used. Grade selection is based on viscosity grade, substitution type, regulatory compliance, and documentation requirements.

Aplicações Típicas

  • Tablet binder (wet granulation & direct compression)
  • Film coating for immediate-release tablets
  • Matrix former for controlled-release tablets
  • HPMC capsule shell material (vegetarian alternative)
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  • Ophthalmic solutions & artificial tear formulations
  • Topical and semi-solid pharmaceutical systems

Aplicações farmacêuticas requerem seleção de grau adequada, conformidade com farmacopeias e documentação relevante. Entre em contato com LANDERCOLL para discutir a disponibilidade de grau farmacêutico.

Discuss Pharma Grades
Food · E464

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Aplicações Típicas

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Aplicações Industriais

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Industrial coatings application
Revestimentos à Base de Água

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Revestimentos Texturizados

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Ceramic Processing

Green body forming, extrusion, pressing — binding, green strength, and suspension support before firing.

Textile Printing Pastes

Viscosity control and rheology management in textile printing formulations.

Paper Coating & Sizing

Film formation, binding, and surface integrity in paper coating and sizing applications.

Specialty Industrial Fluids

Thickening, process control, and stability in specialty fluid formulations across various industrial sectors.

Agricultural Formulations

Viscosity building, suspension stability, and film formation in selected agricultural product systems.

Comparação de Produtos

HPMC vs Other
Éteres de celulose

Cellulose ethers are a family of water-soluble polymers, each with distinct chemical structures and performance profiles. LANDERCOLL supplies HPMC, HEMC/MHEC, HEC, and CMC — the four most widely used in industrial formulation. Understanding the differences helps formulators select the most appropriate product.

HPMC
Hidroxipropilmetilcelulose
Não iônico

Versatile water retention, thickening, film forming, workability, broad application compatibility.

Construção · Farmacêutico · Alimentício · Cuidados pessoais · Detergentes · Industrial
HEMC
Hydroxyethyl Methyl Cellulose (MHEC)
Não iônico

Strong construction performance, excellent water retention, good anti-sag in drymix mortar.

Tile adhesive · Wall putty · Cement plaster · Gypsum · EIFS/ETICS
HEC
Hidroxietilcelulose
Não iônico

Excellent rheology control in aqueous systems, strong latex compatibility for coatings.

Water-based paints · Coatings · Cleaners · Personal care
CMC
Carboximetil Celulose
Aniônico

Thickening, binding, stabilization, texture control; cost-effective across many systems.

Food · Detergents · Ceramics · Pharma · Oilfield · Paper

HPMC vs HEMC/MHEC for Construction

Both are non-ionic cellulose ethers for drymix construction materials and can deliver similar core functions. The choice depends on specific performance targets, regional market preferences, formulation system, and cost considerations. In many markets, HEMC/MHEC is preferred for high-performance tile adhesive and plaster due to its water retention profile. HPMC remains widely used globally across a broader range of industries.

HPMC vs HEC for Coatings

For water-based architectural coatings and latex paint systems, HEC is generally the preferred cellulose ether due to its strong compatibility with latex polymers and its well-established use in paint formulation. HPMC may be considered in specific coating systems, texture coatings, or where its film-forming or thermal gelation properties offer a formulation advantage.

Por Indústria

HPMC Grade Directions
por Indústria

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Grade Direction · i.
Grau de Construção

Designed for drymix construction materials requiring water retention, workability improvement, open time extension, anti-sag performance, and application consistency. Surface-treated grades commonly used.

Tile adhesive · Wall putty · Cement plaster · Gypsum plaster · Masonry mortar · Self-leveling · EIFS/ETICS · Waterproof mortar · Repair mortar · Insulation mortar
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Grade Direction · ii.
Grau de Detergente

Designed for home care and cleaning systems where viscosity building, texture stability, product body, and storage stability are important. Compatible with common anionic and non-ionic surfactant systems.

Laundry liquid · Dishwashing liquid · Toilet cleaner · Surface cleaner · Gel cleaner
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Grade Direction · iii.
Grau de Cuidados Pessoais

Designed for personal care products where smooth texture, stable viscosity, and user-friendly application feel are required. Non-ionic and compatible with a wide range of personal care actives.

Shampoo · Body wash · Facial cleanser · Lotion · Cream · Toothpaste · Styling products
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Grade Direction · iv.
Pharmaceutical Grade (Hypromellose)

Manufactured and tested to pharmacopoeial standards (USP/NF, Ph. Eur., JP). For pharmaceutical excipient applications where binding, coating, controlled release, or film performance may be required.

Tablet binder · Film coating · Controlled-release matrix · HPMC capsule shells · Oral film systems · Ophthalmic applications
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Industrial Grade

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Logística e Documentação

Embalagem, Armazenamento e Documentos Disponíveis

Embalagem e Armazenamento

Embalagem e Armazenamento

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Embalagem Padrão

  • 25 kg por saco
  • Saco de papel com forro interno de polietileno protetor contra umidade
  • Embalagem paletizada disponível mediante solicitação
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Recomendações de Armazenamento

  • Armazenar em ambiente fresco, seco e bem ventilado
  • Manter longe de umidade, luz solar direta e fontes de calor
  • Manter a embalagem fechada quando não estiver em uso
  • Evitar contaminação durante o manuseio e transferência
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  • Não armazenar próximo a agentes oxidantes fortes ou produtos químicos reativos
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Documentação

Documentação do Produto
Disponível mediante solicitação

A LANDERCOLL pode fornecer documentação relacionada ao produto para apoiar a avaliação de formulações, revisão de compras, comunicação técnica, submissão regulatória e processos internos de aprovação.

Documentos Disponíveis

  • Ficha de Dados Técnicos (FDT)
  • Ficha de Dados de Segurança (FDS / MSDS)
  • Certificado de Análise (COA)
  • Folder do produto e guia de aplicação
  • Documento de recomendação de grau
  • Especificação de embalagem e armazenamento
  • Documentação relacionada à exportação, quando aplicável

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Solicitar Documentos do Produto
Guia de Consulta

Como Solicitar o
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PERGUNTAS FREQUENTES

Perguntas frequentes
About HPMC

What is HPMC used for?

HPMC (CAS 9004-65-3) is used as a multifunctional cellulose ether additive across many industries. Its primary functions include water retention, thickening, workability improvement, film formation, binding, and formulation stabilization. Most widely used in drymix construction materials, and also in detergents, personal care, pharmaceutical excipients, food systems (E464), coatings, ceramics, and specialty industrial applications.

What does HPMC do in tile adhesive?

In tile adhesive, HPMC improves water retention to support cement hydration, extends open time to give installers more working time, provides anti-slip behavior to prevent tiles from sliding on vertical surfaces, and improves troweling feel and application consistency. High to extra-high viscosity grades are typically used, at dosages of 0.2%–0.5% of the dry mix weight.

What viscosity of HPMC is used for tile adhesive?

Tile adhesive commonly uses high to extra-high viscosity HPMC, typically in the range of 50,000–200,000 mPa·s (measured at 2% aqueous solution). The exact viscosity grade depends on the formulation type, tile size and weight, required open time, anti-slip performance target, and application conditions. Final grade selection should be confirmed through formulation testing.

What is the typical dosage of HPMC in tile adhesive?

The typical reference dosage for HPMC in tile adhesive is 0.2%–0.5% by weight of the dry mix. This range is widely referenced in the drymix mortar industry as a starting point. However, the optimal dosage depends on the specific formulation, cement type, filler quality, target open time, water retention requirement, and application conditions. Final dosage must be confirmed through laboratory and field testing.

What does HPMC do in wall putty?

In wall putty and skim coat, HPMC improves water retention to prevent rapid drying, enhances scraping smoothness and surface finish quality, improves spreading behavior and workability, and helps maintain consistent product texture during application. Medium to high viscosity grades are typically used at dosages of 0.2%–0.5%.

What is the difference between HPMC and HEMC?

HPMC uses hydroxypropyl groups while HEMC uses hydroxyethyl groups on the cellulose backbone, affecting water retention profile, dissolution behavior, and performance in specific applications. Both are used in tile adhesive, wall putty, and plaster. HPMC is more widely used across multiple industries including pharma, food, and personal care, while HEMC/MHEC is particularly established in European drymix construction markets.

Is HPMC the same as Hypromellose?

Yes. Hypromellose is the International Nonproprietary Name (INN) and pharmacopoeial name for HPMC. It is used in pharmaceutical and food regulatory contexts. HPMC and Hypromellose refer to the same chemical substance (CAS 9004-65-3).

Is HPMC a food additive?

Yes. HPMC is approved as a food additive under the code E464 in the European Union and is recognized in food regulations in many other markets. Food applications require suitable food-grade HPMC that meets applicable purity and safety standards, and compliance with the specific food regulations of the target market is required.

Is HPMC used in pharmaceuticals?

Yes. Suitable pharmaceutical grades — referred to as Hypromellose — are widely used as excipients in tablet manufacturing, film coating, controlled-release systems, HPMC capsule shells, and ophthalmic formulations. HPMC is listed in the USP/NF, Ph. Eur., and JP pharmacopoeias. Pharmaceutical applications require grades manufactured and tested to pharmacopoeial standards.

What is the difference between surface-treated and non-surface-treated HPMC?

Surface-treated HPMC delays hydration when it contacts water, preventing premature lump formation and allowing the powder to disperse evenly before viscosity develops — commonly preferred in drymix mortar systems. Non-surface-treated HPMC dissolves more quickly and is preferred in systems where fast viscosity development is required.

Como escolho o grau correto de HPMC?

The right HPMC grade depends on your application, required viscosity level, formulation system type (cement-based, gypsum-based, liquid, semi-solid), processing conditions, dissolution behavior requirement, and final performance targets. Contact LANDERCOLL with your application details, and our team can recommend suitable grade directions and support your formulation evaluation.

Can HPMC be used in multiple industries?

Yes. HPMC is one of the most versatile cellulose ethers, used across construction, home care, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors. Different industries require different grade selections — contact LANDERCOLL to identify the most suitable grade direction for your specific application and market.

Por que LANDERCOLL

Por que Escolher LANDERCOLL HPMC

i.

Especialização Focada em Éter de Celulose

LANDERCOLL focuses on cellulose ether products — HPMC, HEMC/MHEC, HEC, and CMC. This product focus allows us to develop deeper application knowledge and provide more relevant technical support compared to general chemical distributors.

ii.

Application-Oriented Grade Matching

We help customers select HPMC based on real performance requirements — water retention, viscosity level, workability, open time, texture, stability, and processing behavior — rather than simply offering a product catalog.

iii.

Cobertura Ampla de Indústrias

LANDERCOLL HPMC supports customers in construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors across multiple global markets.

iv.

Suporte à Documentação Técnica

We provide TDS, SDS, COA, product recommendation documents, and application guides to support your evaluation, purchasing review, and internal approval processes.

v.

Parceria de Fornecimento a Longo Prazo

Nosso objetivo é apoiar os clientes desde a consulta inicial do produto até testes de formulação, decisões de sourcing e cooperação de fornecimento a longo prazo — com qualidade de produto consistente e comunicação ágil.

Entre em Contato

Find the Right HPMC Grade
para Sua aplicação

LANDERCOLL HPMC supports manufacturers across construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial applications. Whether you are developing a new formulation, optimizing an existing product, or evaluating a new cellulose ether supplier, our team can help you identify the most suitable grade and provide the documentation and technical support you need.

~ Sua consulta · MMXXV ~
Produto HPMC · CAS 9004-65-3
Aplicativo Sua formulação alvo
Direção de Grau Low · Medium · High · XH
Surface Treatment Treated or non-treated
Documentos TDS · SDS · COA
Mercado País e segmento
Indústrias Construction · Pharma · Food · Care