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CAS 9004-65-3 · E464 EINECS 618-389-1

HPMC Hydroksypropylmetylcellulose

Definition, Chemistry, and Industrial Role — a complete reference for formulators across construction, pharma, food, personal care, and industrial sectors.

HPMC is a water-soluble, non-ionic cellulose ether produced by chemically modifying natural cellulose derived from wood pulp or cotton linter. It delivers multiple functional benefits — water retention, thickening, film forming, binding, and workability improvement — within a single versatile ingredient.

~ Quick Reference ~
Fullstendig navn Hydroksypropylmetylcellulose
CAS No. 9004-65-3
Food Code E464
Ionic Type Ikke-ionisk
Løselighet Cold water soluble
Pharma Name Hypromellose
Utseende Hvitt til off-white pulver
Kjemi
Cellulose ether chemistry lab
DS·MS Substitution
Lab analysis Chemical structure
What Is HPMC?

Definition, Chemistry,
og Industrial Role

HPMC is produced by reacting purified cellulose with methyl chloride and propylene oxide under controlled alkaline conditions. This process introduces two types of substituent groups onto the cellulose backbone, each influencing the final product's performance profile in different ways.

Methoxyl Groups (–OCH₃)

Control solubility, thermal gelation behavior, and surface activity of the cellulose ether.

Hydroxypropoxyl Groups

Influence water retention capacity, viscosity development, and compatibility with other ingredients.

The combination and ratio of these two substituents — expressed as degree of methyl substitution (DS) and molar substitution of hydroxypropyl (MS) — determine the grade's performance profile. Viscosity, measured at 2% aqueous solution using Brookfield or Ubbelohde methods, is the most commonly referenced parameter for grade selection, ranging from below 100 mPa·s to above 200,000 mPa·s depending on the grade.

Why HPMC Is Widely Used

HPMC is non-ionic — compatible with a wide range of additives, surfactants, salts, and pH conditions. It is also biodegradable, odorless, tasteless, and free from animal-derived raw materials, making it suitable for regulated and sensitive applications from drymix mortar to pharmaceutical excipients and food systems.

Teknisk data

HPMC Technical
Reference Data

The following table provides a general technical reference for Hydroxypropyl Methyl Cellulose. Exact values vary by product grade, viscosity level, substitution type, particle size, surface treatment, and testing method. This information is intended as a formulation reference starting point, not a final product specification.

ItemTypical Reference
ProduktnavnHydroksypropylmetylcellulose
AbbreviationHPMC
CAS No.9004-65-3
Food Additive CodeE464
UtseendeHvitt til off-white pulver
Ionic TypeIkke-ionisk
Molecular BasisCellulose ether (modified natural cellulose)
Raw Material SourceWood pulp or cotton linter
LøselighetSoluble in cold water; insoluble in hot water above gelation temperature; forms viscous solution
Termisk geleringGels upon heating; re-dissolves upon cooling (thermally reversible)
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Karakterer
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i.
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ii.
Medium Viscosity HPMC
Typically 5,000–50,000 mPa·s
Wall putty, skim coat, detergent, personal care, general industrial systems.
Texture · Viscosity building · Smooth workability
iii.
High Viscosity HPMC
Typically 50,000–150,000 mPa·s
Tile adhesive, cement plaster, gypsum plaster, drymix mortar systems.
Water retention · Open time · Workability
iv.
Extra High Viscosity HPMC
Typically above 150,000 mPa·s
High-performance tile adhesive, thick-layer mortar, vertical application systems.
Strong water retention · Anti-sag · Extended open time
v.
Grades by Surface Treatment
Treated or non-treated options
Surface-Treated

Delayed hydration — easier dispersion, reduced lumping, controlled dissolution. Preferred for drymix systems.

Non-Surface-Treated

Faster viscosity development — quick hydration, suitable for fast-dissolving and direct-hydration formulations.

Note: Viscosity ranges listed above are approximate references. Actual LANDERCOLL HPMC grades should be selected according to your formulation, testing method, application environment, and required documentation. Contact our team for specific grade recommendations.

Core Functions

Key Functions of
HPMC in Formulation

HPMC is a multifunctional cellulose ether. In most applications, it contributes more than one functional benefit simultaneously. Below is a structured overview of its primary functions across different system types.

Oppbevaring av vann
i.
Oppbevaring av vann

In cement-based and gypsum-based systems, HPMC forms a polymer network that physically restricts water migration. Higher viscosity grades and higher dosage levels provide stronger water retention — preventing rapid water loss, incomplete hydration, and surface cracking.

Fortykning
ii.
Thickening & Viscosity Control

HPMC dissolves in cold water to form a viscous, pseudoplastic (shear-thinning) solution. Viscosity decreases under shear during mixing and recovers at rest — supporting both processability and in-place stability across drymix mortar, detergents, personal care, and coatings.

Bearbeidbarhet
iii.
Workability Improvement

In drymix construction materials, HPMC makes mortar smoother, more cohesive, and easier to spread, trowel, scrape, and finish. It is a combined result of water retention, viscosity building, and lubrication effects — particularly valued in tile adhesive, wall putty, and gypsum plaster.

iv.
Rheologikontroll

Supports flow control, sag resistance, leveling behavior, and application stability. Prevents mortar from sliding on vertical surfaces, contributes to controlled flow in self-leveling compounds, and maintains stable viscosity in coatings and detergents.

v.
Filmdannelse

HPMC forms a continuous, flexible film after water evaporation — used in pharmaceutical tablet coating, edible film systems, construction surface integrity, and selected water-based coatings as a binder component.

vi.
Binding, Cohesion & Suspension

Supports structural integrity in tablet manufacturing, green strength in ceramics, and cohesion in drymix mortar. Also helps maintain uniform suspension of pigments, fillers, mineral powders, and active ingredients in coatings, detergents, and pharmaceutical systems.

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HPMC Application
Selection Guide

HPMC grade selection should always start from the application. A grade optimized for tile adhesive will not necessarily perform well in a detergent, personal care, or pharmaceutical system. The table below provides a structured reference for common application-to-grade matching.

SøknadRecommended Grade DirectionMain Performance Requirements
FlislimHigh to extra-high viscosityWater retention, open time, anti-slip, troweling feel
Veggsparkel / Skim CoatMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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GipspussMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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Vanntett mørtelMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
MurmørtelMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
ReparasjonsmørtelMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Flytende vaskemiddelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Personlig pleiecURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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KeramikkMedium to high viscositycURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Vannbaserte beleggcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Industrial AdhesivesMedium to high viscosityBinding, cohesion, process stability

Grade direction is a starting reference. Final selection should be confirmed through laboratory testing under your specific formulation conditions, water quality, temperature range, and application method.

Dosage Guide

HPMC Dosage Reference
by Application

HPMC dosage depends on formulation design, raw material quality, target performance, ambient temperature, water quality, substrate type, and production process. The following ranges are general starting points for laboratory evaluation — not fixed usage standards.

For tile adhesive: 0.2%–0.5% is a widely referenced industry starting range. However, final dosage must be confirmed through laboratory testing and on-site performance evaluation, as substrate porosity, tile size, ambient temperature, and cement type all affect the optimal dosage.

Mortar application dosage
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FlislimcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Veggsparkel / Skim CoatcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Sementpuss / pusscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
GipspusscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
MurmørtelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Selvutjevnende forbindelser0.05% – 0.2%
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Vanntett mørtelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
ReparasjonsmørtelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Flytende vaskemiddelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
Personlig pleiecURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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Food / Pharma / SpecialtyDepends on grade, regulation, and formulation design

These dosage ranges are general starting points. Adjust based on testing results under your specific formulation, raw materials, and application conditions.

Bruksområder

Bygging &Drymix-mørtel

Construction is the largest and most established application area for HPMC globally — a critical additive for water retention, workability, open time, and anti-sag performance.

In drymix mortar systems, HPMC functions simultaneously as a water-retaining agent, rheology modifier, and workability enhancer. Without HPMC, cement-based and gypsum-based mortars tend to lose water too quickly to the substrate, resulting in poor hydration, weak bond strength, surface cracking, and difficult application.

Flislim

Water retention, open time extension, anti-slip behavior, and troweling feel. High to extra-high viscosity grades, 0.2%–0.5% dosage. Surface-treated grades commonly preferred.

Wall Putty & Skim Coat

Scraping smoothness, water retention, surface finish quality. Medium to high viscosity, 0.2%–0.5% dosage.

Gypsum-Based Products

Controlled water retention without over-retarding set time. Smooth spreading, consistent texture, reduced surface defects. Medium to high viscosity grades.

Other Mortar Systems

Cement render, masonry mortar, self-leveling compounds, EIFS/ETICS, waterproof mortar, repair mortar, insulation mortar, joint fillers.

All Construction Applications
  • Flislim
  • Wall putty & skim coat
  • Cement render & plaster
  • Gipspuss
  • Selvnivellerende masser
  • EIFS / ETICS mørtel
  • Vanntett mørtel
  • Murmørtel
  • Reparasjonsmørtel
  • Isolasjonsmørtel
  • Joint fillers
  • Ready-mix dry mortar systems
Bruksområder

Home Care & Personal Care Formuleringer

Home care detergents Hjemmepleie og vaskemidler

HPMC for Home Care
& Detergent Formulations

As a non-ionic polymer, HPMC is compatible with anionic and non-ionic surfactant systems commonly used in cleaning products. It builds smooth, stable viscosity that improves product appearance, pourability, and consumer perception — while helping maintain uniform suspension of insoluble components.

Typiske applikasjoner

Laundry liquid Dishwashing liquid Toilet bowl cleaner Surface cleaner Gel cleaner Multi-purpose cleaner
  • Controlled viscosity and product body
  • Stable texture and appearance over shelf life
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Personal care products Personlig pleie

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Typiske applikasjoner

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Farmasøytisk

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Typiske applikasjoner

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  • Oral film systems
  • Ophthalmic solutions & artificial tear formulations
  • Topical and semi-solid pharmaceutical systems

Pharmaceutical applications require suitable grade selection, pharmacopoeial compliance, and relevant documentation. Contact LANDERCOLL to discuss pharmaceutical grade availability.

Discuss Pharma Grades
Food · E464

HPMC for Food Applications (E464)

Hydroxypropyl Methyl Cellulose is approved as a food additive under E464 in the European Union and is recognized in food regulations in many other markets. Suitable food-grade HPMC may be used as a thickener, stabilizer, emulsifier, film former, and texture modifier.

Food applications require HPMC grades meeting relevant food safety standards including purity specifications, heavy metal limits, and microbiological requirements. Compliance with the specific food regulations of the target market is required.

Typiske applikasjoner

  • Bakery products including gluten-free formulations
  • Sauces, dressings, and condiments
  • Frozen food systems (ice cream, frozen desserts)
  • Beverage systems
  • Edible film and coating applications
  • Vegetarian & vegan food products (gelatin alternative)
  • Thermal gelation: gels when heated, re-dissolves when cooled
  • Improved freeze-thaw stability
  • Suitable for vegetarian, vegan, and halal-compliant formulations

Food applications require suitable grade selection and compliance with applicable food regulations in the target market.

Discuss Food Grades
Coatings & Industrial

HPMC for Coatings and
Industrielle applikasjoner

HPMC can be used in selected water-based coatings and specialty industrial systems where thickening, film formation, binding, suspension control, and process stability are required. In architectural coatings, HEC is more commonly used as the primary cellulose ether thickener; however, HPMC can be suitable in specific coating formulations and industrial systems.

Key performance benefits include viscosity control and thickening, film formation and surface integrity, binding and cohesion in ceramic and industrial systems, suspension stability for pigments and fillers, and process consistency in extrusion and forming operations.

Industrial coatings application
Vannbaserte belegg

Selected architectural and decorative systems where HPMC's film-forming or thermal gelation properties offer a formulation advantage.

Teksturbelegg

Decorative and texture coatings requiring stable viscosity, film formation, and consistent application behavior.

Construction Adhesives & Sealants

Binding, cohesion support, and process stability in adhesive and sealant formulations.

Ceramic Processing

Green body forming, extrusion, pressing — binding, green strength, and suspension support before firing.

Textile Printing Pastes

Viscosity control and rheology management in textile printing formulations.

Paper Coating & Sizing

Film formation, binding, and surface integrity in paper coating and sizing applications.

Specialty Industrial Fluids

Thickening, process control, and stability in specialty fluid formulations across various industrial sectors.

Agricultural Formulations

Viscosity building, suspension stability, and film formation in selected agricultural product systems.

Product Comparison

HPMC vs Other
Celluloseethere

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HPMC
Hydroksypropylmetylcellulose
Ikke-ionisk

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HEMC
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Ikke-ionisk

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HEC
Hydroksyetylcellulose
Ikke-ionisk

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CMC
Karboksymetylcellulose
Anionisk

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Construction grade
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Bygningsklasse

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Detergent grade
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Vaskemiddelklasse

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Laundry liquid · Dishwashing liquid · Toilet cleaner · Surface cleaner · Gel cleaner
Personal care grade
Grade Direction · iii.
Personlig pleie-klasse

Designed for personal care products where smooth texture, stable viscosity, and user-friendly application feel are required. Non-ionic and compatible with a wide range of personal care actives.

Shampoo · Body wash · Facial cleanser · Lotion · Cream · Toothpaste · Styling products
Pharmaceutical grade
Grade Direction · iv.
Pharmaceutical Grade (Hypromellose)

Manufactured and tested to pharmacopoeial standards (USP/NF, Ph. Eur., JP). For pharmaceutical excipient applications where binding, coating, controlled release, or film performance may be required.

Tablet binder · Film coating · Controlled-release matrix · HPMC capsule shells · Oral film systems · Ophthalmic applications
Food grade E464
Grade Direction · v.
Food Grade (E464)

Compliant with applicable food additive regulations. Designed for food systems where texture control, water management, stabilization, and formulation consistency are required.

Bakery products · Sauces & dressings · Frozen food · Edible films · Texture-modified food · Vegan & halal applications
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Grade Direction · vi.
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Designed for specialty industrial systems requiring thickening, binding, suspension stability, and process control across various non-food, non-pharma applications.

Ceramics processing · Construction adhesives · Textile printing · Paper-related systems · Specialty industrial fluids
Logistics & Documentation

Packaging, Storage & cURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits

Packaging & Storage

Packaging and Storage

LANDERCOLL HPMC is supplied in industrial packaging suitable for transportation, storage, and production handling. Cellulose ether powders are hygroscopic — proper storage conditions help maintain powder flowability, dissolution performance, and application effectiveness throughout product shelf life.

Standard Packaging

  • 25 kg per bag
  • Paper bag with inner moisture-protective polyethylene liner
  • Palletized packaging available upon request
  • Customized packaging options can be discussed for long-term supply cooperation

Storage Recommendations

  • Store in a cool, dry, and well-ventilated environment
  • Keep away from moisture, direct sunlight, and heat sources
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  • Avoid contamination during handling and transfer
  • Use within the recommended shelf life stated in product documentation
  • Do not store near strong oxidizing agents or reactive chemicals
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Documentation

Product Documentation
Available on Request

LANDERCOLL can provide product-related documentation to support formulation evaluation, purchasing review, technical communication, regulatory submission, and internal approval processes.

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  • Technical Data Sheet (TDS)
  • Safety Data Sheet (SDS / MSDS)
  • Certificate of Analysis (COA)
  • Product brochure and application guide
  • Grade recommendation document
  • Packaging and storage specification
  • Export-related documentation, where applicable

All documentation is provided to help customers complete their internal evaluation, purchasing approval, and regulatory review processes efficiently. Contact our team to request specific documents for your application or market requirements.

Request Product Documents
Inquiry Guide

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VANLIGE SPØRSMÅL

Ofte stilte spørsmål
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In wall putty and skim coat, HPMC improves water retention to prevent rapid drying, enhances scraping smoothness and surface finish quality, improves spreading behavior and workability, and helps maintain consistent product texture during application. Medium to high viscosity grades are typically used at dosages of 0.2%–0.5%.

What is the difference between HPMC and HEMC?

HPMC uses hydroxypropyl groups while HEMC uses hydroxyethyl groups on the cellulose backbone, affecting water retention profile, dissolution behavior, and performance in specific applications. Both are used in tile adhesive, wall putty, and plaster. HPMC is more widely used across multiple industries including pharma, food, and personal care, while HEMC/MHEC is particularly established in European drymix construction markets.

Is HPMC the same as Hypromellose?

Yes. Hypromellose is the International Nonproprietary Name (INN) and pharmacopoeial name for HPMC. It is used in pharmaceutical and food regulatory contexts. HPMC and Hypromellose refer to the same chemical substance (CAS 9004-65-3).

Is HPMC a food additive?

Yes. HPMC is approved as a food additive under the code E464 in the European Union and is recognized in food regulations in many other markets. Food applications require suitable food-grade HPMC that meets applicable purity and safety standards, and compliance with the specific food regulations of the target market is required.

Is HPMC used in pharmaceuticals?

Yes. Suitable pharmaceutical grades — referred to as Hypromellose — are widely used as excipients in tablet manufacturing, film coating, controlled-release systems, HPMC capsule shells, and ophthalmic formulations. HPMC is listed in the USP/NF, Ph. Eur., and JP pharmacopoeias. Pharmaceutical applications require grades manufactured and tested to pharmacopoeial standards.

What is the difference between surface-treated and non-surface-treated HPMC?

Surface-treated HPMC delays hydration when it contacts water, preventing premature lump formation and allowing the powder to disperse evenly before viscosity develops — commonly preferred in drymix mortar systems. Non-surface-treated HPMC dissolves more quickly and is preferred in systems where fast viscosity development is required.

Hvordan velger jeg riktig HPMC-kvalitet?

The right HPMC grade depends on your application, required viscosity level, formulation system type (cement-based, gypsum-based, liquid, semi-solid), processing conditions, dissolution behavior requirement, and final performance targets. Contact LANDERCOLL with your application details, and our team can recommend suitable grade directions and support your formulation evaluation.

Can HPMC be used in multiple industries?

Yes. HPMC is one of the most versatile cellulose ethers, used across construction, home care, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors. Different industries require different grade selections — contact LANDERCOLL to identify the most suitable grade direction for your specific application and market.

Hvorfor LANDERCOLL

Hvorfor velge LANDERCOLL HPMC

i.

Fokusert ekspertise innen cellulosether

LANDERCOLL focuses on cellulose ether products — HPMC, HEMC/MHEC, HEC, and CMC. This product focus allows us to develop deeper application knowledge and provide more relevant technical support compared to general chemical distributors.

ii.

Application-Oriented Grade Matching

We help customers select HPMC based on real performance requirements — water retention, viscosity level, workability, open time, texture, stability, and processing behavior — rather than simply offering a product catalog.

iii.

Bred bransjedekning

LANDERCOLL HPMC supports customers in construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors across multiple global markets.

iv.

Technical Documentation Support

We provide TDS, SDS, COA, product recommendation documents, and application guides to support your evaluation, purchasing review, and internal approval processes.

v.

Long-Term Supply Partnership

We aim to support customers from initial product inquiry through formulation testing, sourcing decisions, and long-term supply cooperation — with consistent product quality and responsive communication.

Kontakt oss

Find the Right HPMC Grade
for Din søknad

LANDERCOLL HPMC supports manufacturers across construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial applications. Whether you are developing a new formulation, optimizing an existing product, or evaluating a new cellulose ether supplier, our team can help you identify the most suitable grade and provide the documentation and technical support you need.

~ Din forespørsel · MMXXV ~
Produkt HPMC · CAS 9004-65-3
Søknad Din målformulering
Grade Direction Low · Medium · High · XH
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Dokumenter TDS · SDS · COA
Marked Land & segment
Industrier Construction · Pharma · Food · Care