CAS 9004-65-3 · E464 EINECS 618-389-1

HPMC Hydroxypropylmethylcellulose

Definition, Chemistry, and Industrial Role — a complete reference for formulators across construction, pharma, food, personal care, and industrial sectors.

HPMC is a water-soluble, non-ionic cellulose ether produced by chemically modifying natural cellulose derived from wood pulp or cotton linter. It delivers multiple functional benefits — water retention, thickening, film forming, binding, and workability improvement — within a single versatile ingredient.

~ Quick Reference ~
Volledige naam Hydroxypropylmethylcellulose
CAS No. 9004-65-3
Food Code E464
Ionic Type Niet-ionisch
Oplosbaarheid Cold water soluble
Pharma Name Hypromellose
Uiterlijk Wit tot gebroken wit poeder
Chemie
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DS·MS Substitution
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What Is HPMC?

Definition, Chemistry,
en Industrial Role

HPMC is produced by reacting purified cellulose with methyl chloride and propylene oxide under controlled alkaline conditions. This process introduces two types of substituent groups onto the cellulose backbone, each influencing the final product's performance profile in different ways.

Methoxyl Groups (–OCH₃)

Control solubility, thermal gelation behavior, and surface activity of the cellulose ether.

Hydroxypropoxyl Groups

Influence water retention capacity, viscosity development, and compatibility with other ingredients.

The combination and ratio of these two substituents — expressed as degree of methyl substitution (DS) and molar substitution of hydroxypropyl (MS) — determine the grade's performance profile. Viscosity, measured at 2% aqueous solution using Brookfield or Ubbelohde methods, is the most commonly referenced parameter for grade selection, ranging from below 100 mPa·s to above 200,000 mPa·s depending on the grade.

Why HPMC Is Widely Used

HPMC is non-ionic — compatible with a wide range of additives, surfactants, salts, and pH conditions. It is also biodegradable, odorless, tasteless, and free from animal-derived raw materials, making it suitable for regulated and sensitive applications from drymix mortar to pharmaceutical excipients and food systems.

Technische Gegevens

HPMC Technical
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The following table provides a general technical reference for Hydroxypropyl Methyl Cellulose. Exact values vary by product grade, viscosity level, substitution type, particle size, surface treatment, and testing method. This information is intended as a formulation reference starting point, not a final product specification.

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ProductnaamHydroxypropylmethylcellulose
AbbreviationHPMC
CAS No.9004-65-3
Food Additive CodeE464
UiterlijkWit tot gebroken wit poeder
Ionic TypeNiet-ionisch
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OplosbaarheidSoluble in cold water; insoluble in hot water above gelation temperature; forms viscous solution
Thermische gelvormingcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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Belangrijkste functiesThickening, water retention, film forming, binding, workability, stabilization
Application SystemsDrymix, liquid, semi-solid, pharmaceutical, food, industrial
Available DocumentsTDS, SDS, COA, product recommendation available on request

Important: This table is a general reference only. For exact viscosity, pH, moisture content, ash content, particle size distribution, methoxyl content, hydroxypropoxyl content, and grade-specific values, please request the official TDS or COA from LANDERCOLL.

Rangen
Grade Reference

HPMC Product Grades —
Viscosity and Application Reference

LANDERCOLL HPMC is available in multiple grade directions based on viscosity level, surface treatment, dissolution behavior, and target application. The information below is designed as a product selection reference. Final grade selection should always be confirmed through formulation testing and direct technical discussion with our team.

i.
Low Viscosity HPMC
Typically below 5,000 mPa·s
Coatings, pharmaceutical tablet coating, food systems, selected liquid formulations.
Film formation · Light thickening · Flow control
ii.
Medium Viscosity HPMC
Typically 5,000–50,000 mPa·s
Wall putty, skim coat, detergent, personal care, general industrial systems.
Texture · Viscosity building · Smooth workability
iii.
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iv.
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Typically above 150,000 mPa·s
High-performance tile adhesive, thick-layer mortar, vertical application systems.
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v.
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Surface-Treated

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Non-Surface-Treated

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Water vasthouden
i.
Water vasthouden

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Indikken
ii.
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Verwerkbaarheid
iii.
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iv.
Rheologie Controle

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v.
Filmvorming

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vi.
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Toelichting voor toepassing

HPMC Application
Selectiegids

HPMC grade selection should always start from the application. A grade optimized for tile adhesive will not necessarily perform well in a detergent, personal care, or pharmaceutical system. The table below provides a structured reference for common application-to-grade matching.

ToepassingcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsMain Performance Requirements
TegellijmHigh to extra-high viscosityWater retention, open time, anti-slip, troweling feel
Muurplamuur / Skim CoatcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsSmooth scraping, water retention, surface finish
CementpleistercURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsWorkability, spreadability, water retention
GipscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsSmooth application, water management, consistency
Zelfnivellerende verbindingencURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsFlow control, stability, controlled water retention
EIFS / ETICS MortelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsOpen time, anti-sag, adhesion-related support
Waterdichte mortelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsWorkability, uniform coating, stable consistency
MetselmortelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsWater retention, workability, bond support
HerstellingsmortelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsAdhesion, workability, water retention
Vloeibaar wasmiddelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsTexture, viscosity, storage stability
Persoonlijke verzorgingcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsSmooth texture, viscosity control, stability
Pharmaceutical ApplicationsSuitable pharmaceutical gradeFilm coating, binding, controlled release, excipient
Food ApplicationsSuitable food grade (E464)Thickening, stabilization, texture control
KeramiekcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsBinding, green strength, suspension
Watergedragen coatingscURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsThickening, film formation, particle suspension
Industrial AdhesivescURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsBinding, cohesion, process stability

Grade direction is a starting reference. Final selection should be confirmed through laboratory testing under your specific formulation conditions, water quality, temperature range, and application method.

Dosering Gids

HPMC Dosage Reference
by Application

HPMC dosage depends on formulation design, raw material quality, target performance, ambient temperature, water quality, substrate type, and production process. The following ranges are general starting points for laboratory evaluation — not fixed usage standards.

For tile adhesive: 0.2%–0.5% is a widely referenced industry starting range. However, final dosage must be confirmed through laboratory testing and on-site performance evaluation, as substrate porosity, tile size, ambient temperature, and cement type all affect the optimal dosage.

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Tegellijm0.2% – 0.5%
Muurplamuur / Skim Coat0.2% – 0.5%
Cementpleister0.15% – 0.4%
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MetselmortelcURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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EIFS / ETICS Mortel0.2% – 0.5%
Waterdichte mortel0.15% – 0.4%
Herstellingsmortel0.15% – 0.4%
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Persoonlijke verzorging0.1% – 1.0%
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Food / Pharma / SpecialtyDepends on grade, regulation, and formulation design

These dosage ranges are general starting points. Adjust based on testing results under your specific formulation, raw materials, and application conditions.

Toepassingen

Constructie &Droog te mengen mortel

Construction is the largest and most established application area for HPMC globally — a critical additive for water retention, workability, open time, and anti-sag performance.

In drymix mortar systems, HPMC functions simultaneously as a water-retaining agent, rheology modifier, and workability enhancer. Without HPMC, cement-based and gypsum-based mortars tend to lose water too quickly to the substrate, resulting in poor hydration, weak bond strength, surface cracking, and difficult application.

Tegellijm

Water retention, open time extension, anti-slip behavior, and troweling feel. High to extra-high viscosity grades, 0.2%–0.5% dosage. Surface-treated grades commonly preferred.

Wall Putty & Skim Coat

Scraping smoothness, water retention, surface finish quality. Medium to high viscosity, 0.2%–0.5% dosage.

Gypsum-Based Products

Controlled water retention without over-retarding set time. Smooth spreading, consistent texture, reduced surface defects. Medium to high viscosity grades.

Other Mortar Systems

Cement render, masonry mortar, self-leveling compounds, EIFS/ETICS, waterproof mortar, repair mortar, insulation mortar, joint fillers.

All Construction Applications
  • Tegellijm
  • Muurvuller & gladde laag
  • Cementpleister & gips
  • Gips
  • Zelfnivellerende compounds
  • EIFS / ETICS mortel
  • Waterdichte mortel
  • Metselmortel
  • Herstellingsmortel
  • Isolatiemortel
  • Joint fillers
  • Ready-mix dry mortar systems
Toepassingen

Home Care & Personal Care Formuleringen

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HPMC for Home Care
& Detergent Formulations

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Typische toepassingen

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Care Formulations

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Typische toepassingen

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Farmaceutisch

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Typische toepassingen

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Pharmaceutical applications require suitable grade selection, pharmacopoeial compliance, and relevant documentation. Contact LANDERCOLL to discuss pharmaceutical grade availability.

Discuss Pharma Grades
Food · E464

HPMC for Food Applications (E464)

Hydroxypropyl Methyl Cellulose is approved as a food additive under E464 in the European Union and is recognized in food regulations in many other markets. Suitable food-grade HPMC may be used as a thickener, stabilizer, emulsifier, film former, and texture modifier.

Food applications require HPMC grades meeting relevant food safety standards including purity specifications, heavy metal limits, and microbiological requirements. Compliance with the specific food regulations of the target market is required.

Typische toepassingen

  • Bakery products including gluten-free formulations
  • Sauces, dressings, and condiments
  • Frozen food systems (ice cream, frozen desserts)
  • Beverage systems
  • Edible film and coating applications
  • Vegetarian & vegan food products (gelatin alternative)
  • Thermal gelation: gels when heated, re-dissolves when cooled
  • Improved freeze-thaw stability
  • Suitable for vegetarian, vegan, and halal-compliant formulations

Food applications require suitable grade selection and compliance with applicable food regulations in the target market.

Discuss Food Grades
Coatings & Industrial

HPMC for Coatings and
Industriële Toepassingen

HPMC can be used in selected water-based coatings and specialty industrial systems where thickening, film formation, binding, suspension control, and process stability are required. In architectural coatings, HEC is more commonly used as the primary cellulose ether thickener; however, HPMC can be suitable in specific coating formulations and industrial systems.

Key performance benefits include viscosity control and thickening, film formation and surface integrity, binding and cohesion in ceramic and industrial systems, suspension stability for pigments and fillers, and process consistency in extrusion and forming operations.

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Watergedragen coatings

Selected architectural and decorative systems where HPMC's film-forming or thermal gelation properties offer a formulation advantage.

Textuurcoatings

Decorative and texture coatings requiring stable viscosity, film formation, and consistent application behavior.

Construction Adhesives & Sealants

Binding, cohesion support, and process stability in adhesive and sealant formulations.

Ceramic Processing

Green body forming, extrusion, pressing — binding, green strength, and suspension support before firing.

Textile Printing Pastes

Viscosity control and rheology management in textile printing formulations.

Paper Coating & Sizing

Film formation, binding, and surface integrity in paper coating and sizing applications.

Specialty Industrial Fluids

Thickening, process control, and stability in specialty fluid formulations across various industrial sectors.

Agricultural Formulations

Viscosity building, suspension stability, and film formation in selected agricultural product systems.

Productvergelijking

HPMC vs Other
Cellulose-ethers

Cellulose ethers are a family of water-soluble polymers, each with distinct chemical structures and performance profiles. LANDERCOLL supplies HPMC, HEMC/MHEC, HEC, and CMC — the four most widely used in industrial formulation. Understanding the differences helps formulators select the most appropriate product.

HPMC
Hydroxypropylmethylcellulose
Niet-ionisch

Versatile water retention, thickening, film forming, workability, broad application compatibility.

Construction · Pharma · Food · Personal care · Detergents · Industrial
HEMC
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Niet-ionisch

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HEC
Hydroxyethylcellulose
Niet-ionisch

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Water-based paints · Coatings · Cleaners · Personal care
CMC
Carboxymethylcellulose
Anionisch

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Food · Detergents · Ceramics · Pharma · Oilfield · Paper

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By Industry

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by Industry

Construction grade
Grade Direction · i.
Constructiegraad

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Detergent grade
Grade Direction · ii.
Detergent Graad

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Personal care grade
Grade Direction · iii.
Persoonlijke Verzorging Graad

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Grade Direction · iv.
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Grade Direction · v.
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Industrial grade
Grade Direction · vi.
Industrial Grade

Designed for specialty industrial systems requiring thickening, binding, suspension stability, and process control across various non-food, non-pharma applications.

Ceramics processing · Construction adhesives · Textile printing · Paper-related systems · Specialty industrial fluids
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Packaging & Storage

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LANDERCOLL HPMC is supplied in industrial packaging suitable for transportation, storage, and production handling. Cellulose ether powders are hygroscopic — proper storage conditions help maintain powder flowability, dissolution performance, and application effectiveness throughout product shelf life.

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  • Customized packaging options can be discussed for long-term supply cooperation

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  • Use within the recommended shelf life stated in product documentation
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Available Documents

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All documentation is provided to help customers complete their internal evaluation, purchasing approval, and regulatory review processes efficiently. Contact our team to request specific documents for your application or market requirements.

Request Product Documents
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Right HPMC Grade

To help our team recommend the most suitable HPMC grade for your application, please include as much of the following information as possible when contacting us. A detailed inquiry allows us to provide a more accurate grade recommendation and support your evaluation more efficiently.

i.
Application & Formulation System

Product application (e.g., tile adhesive, wall putty, shampoo, tablet coating) and formulation system type (cement-based, gypsum-based, liquid, semi-solid, other).

ii.
Current Grade or Viscosity Reference

Current HPMC grade or reference viscosity, if available. Main performance target — e.g., water retention, open time, viscosity level, texture, stability.

iii.
Testing Method & Quantity

Testing method or standard used, if applicable. Required quantity — sample, trial, or commercial volume.

iv.
Market & Documentation

Destination country or target market. Documentation requirements (TDS, SDS, COA, food/pharma compliance documents). Timeline for evaluation or sourcing decision.

FAQ

Veelgestelde vragen
About HPMC

What is HPMC used for?

HPMC (CAS 9004-65-3) is used as a multifunctional cellulose ether additive across many industries. Its primary functions include water retention, thickening, workability improvement, film formation, binding, and formulation stabilization. Most widely used in drymix construction materials, and also in detergents, personal care, pharmaceutical excipients, food systems (E464), coatings, ceramics, and specialty industrial applications.

What does HPMC do in tile adhesive?

In tile adhesive, HPMC improves water retention to support cement hydration, extends open time to give installers more working time, provides anti-slip behavior to prevent tiles from sliding on vertical surfaces, and improves troweling feel and application consistency. High to extra-high viscosity grades are typically used, at dosages of 0.2%–0.5% of the dry mix weight.

What viscosity of HPMC is used for tile adhesive?

Tile adhesive commonly uses high to extra-high viscosity HPMC, typically in the range of 50,000–200,000 mPa·s (measured at 2% aqueous solution). The exact viscosity grade depends on the formulation type, tile size and weight, required open time, anti-slip performance target, and application conditions. Final grade selection should be confirmed through formulation testing.

What is the typical dosage of HPMC in tile adhesive?

The typical reference dosage for HPMC in tile adhesive is 0.2%–0.5% by weight of the dry mix. This range is widely referenced in the drymix mortar industry as a starting point. However, the optimal dosage depends on the specific formulation, cement type, filler quality, target open time, water retention requirement, and application conditions. Final dosage must be confirmed through laboratory and field testing.

What does HPMC do in wall putty?

In wall putty and skim coat, HPMC improves water retention to prevent rapid drying, enhances scraping smoothness and surface finish quality, improves spreading behavior and workability, and helps maintain consistent product texture during application. Medium to high viscosity grades are typically used at dosages of 0.2%–0.5%.

What is the difference between HPMC and HEMC?

HPMC uses hydroxypropyl groups while HEMC uses hydroxyethyl groups on the cellulose backbone, affecting water retention profile, dissolution behavior, and performance in specific applications. Both are used in tile adhesive, wall putty, and plaster. HPMC is more widely used across multiple industries including pharma, food, and personal care, while HEMC/MHEC is particularly established in European drymix construction markets.

Is HPMC the same as Hypromellose?

Yes. Hypromellose is the International Nonproprietary Name (INN) and pharmacopoeial name for HPMC. It is used in pharmaceutical and food regulatory contexts. HPMC and Hypromellose refer to the same chemical substance (CAS 9004-65-3).

Is HPMC a food additive?

Yes. HPMC is approved as a food additive under the code E464 in the European Union and is recognized in food regulations in many other markets. Food applications require suitable food-grade HPMC that meets applicable purity and safety standards, and compliance with the specific food regulations of the target market is required.

Is HPMC used in pharmaceuticals?

Yes. Suitable pharmaceutical grades — referred to as Hypromellose — are widely used as excipients in tablet manufacturing, film coating, controlled-release systems, HPMC capsule shells, and ophthalmic formulations. HPMC is listed in the USP/NF, Ph. Eur., and JP pharmacopoeias. Pharmaceutical applications require grades manufactured and tested to pharmacopoeial standards.

What is the difference between surface-treated and non-surface-treated HPMC?

Surface-treated HPMC delays hydration when it contacts water, preventing premature lump formation and allowing the powder to disperse evenly before viscosity develops — commonly preferred in drymix mortar systems. Non-surface-treated HPMC dissolves more quickly and is preferred in systems where fast viscosity development is required.

Hoe kies ik de juiste HPMC-kwaliteit?

The right HPMC grade depends on your application, required viscosity level, formulation system type (cement-based, gypsum-based, liquid, semi-solid), processing conditions, dissolution behavior requirement, and final performance targets. Contact LANDERCOLL with your application details, and our team can recommend suitable grade directions and support your formulation evaluation.

Can HPMC be used in multiple industries?

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Waarom LANDERCOLL

Waarom Kiezen LANDERCOLL HPMC

i.

Gerichte Expertise in Cellulose Ether

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ii.

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iii.

Brede Industrie Dekking

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iv.

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v.

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Neem contact op

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voor Uw aanvraag

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~ Uw aanvraag · MMXXV ~
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Toepassing Uw doelformulering
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Documenten TDS · SDS · COA
Markt Land & segment
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