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CAS 9004-65-3 · E464 EINECS 618-389-1

HPMC Hydroxypropyl-methylcellulose

Definition, Chemistry, and Industrial Role — a complete reference for formulators across construction, pharma, food, personal care, and industrial sectors.

HPMC is a water-soluble, non-ionic cellulose ether produced by chemically modifying natural cellulose derived from wood pulp or cotton linter. It delivers multiple functional benefits — water retention, thickening, film forming, binding, and workability improvement — within a single versatile ingredient.

~ Hurtig Reference ~
Fuldt navn Hydroxypropyl-methylcellulose
CAS-nummer 9004-65-3
Fødevarekode E464
Ionisk type Ikke-ionisk
Opløselighed Cold water soluble
Pharma Name Hypromellose
Udseende Hvidt til råhvidt pulver
Kemi
Cellulose ether chemistry lab
DS·MS Substitution
Laboratorieanalyse Chemical structure
What Is HPMC?

Definition, Chemistry,
og Industrial Role

HPMC is produced by reacting purified cellulose with methyl chloride and propylene oxide under controlled alkaline conditions. This process introduces two types of substituent groups onto the cellulose backbone, each influencing the final product's performance profile in different ways.

Methoxyl Groups (–OCH₃)

Control solubility, thermal gelation behavior, and surface activity of the cellulose ether.

Hydroxypropoxyl Groups

Influence water retention capacity, viscosity development, and compatibility with other ingredients.

The combination and ratio of these two substituents — expressed as degree of methyl substitution (DS) and molar substitution of hydroxypropyl (MS) — determine the grade's performance profile. Viscosity, measured at 2% aqueous solution using Brookfield or Ubbelohde methods, is the most commonly referenced parameter for grade selection, ranging from below 100 mPa·s to above 200,000 mPa·s depending on the grade.

Why HPMC Is Widely Used

HPMC is non-ionic — compatible with a wide range of additives, surfactants, salts, and pH conditions. It is also biodegradable, odorless, tasteless, and free from animal-derived raw materials, making it suitable for regulated and sensitive applications from drymix mortar to pharmaceutical excipients and food systems.

Teknisk Data

HPMC Technical
Reference Data

The following table provides a general technical reference for Hydroxypropyl Methyl Cellulose. Exact values vary by product grade, viscosity level, substitution type, particle size, surface treatment, and testing method. This information is intended as a formulation reference starting point, not a final product specification.

VareTypisk Reference
Produktets navnHydroxypropyl-methylcellulose
ForkortelseHPMC
CAS-nummer9004-65-3
FødevaretilsætningskodeE464
UdseendeHvidt til råhvidt pulver
Ionisk typeIkke-ionisk
Molekylær basisCelluloseether (modificeret naturlig cellulose)
RåmaterialekildeTræmasse eller bomuldsrester
OpløselighedSoluble in cold water; insoluble in hot water above gelation temperature; forms viscous solution
Termisk geleringGels upon heating; re-dissolves upon cooling (thermally reversible)
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ViskositetsmålingTypically at 2% aqueous solution (Brookfield or Ubbelohde)
cURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsTreated (delayed hydration) or untreated options available
pH-stabilitetStable across approximately pH 3–11
cURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limitsCompatible with non-ionic, anionic, and many cationic systems
NøglefunktionerThickening, water retention, film forming, binding, workability, stabilization
Application SystemsDrymix, liquid, semi-solid, pharmaceutical, food, industrial
Tilgængelige dokumenterTDS, SDS, COA, produktanbefaling tilgængelig på forespørgsel

Important: This table is a general reference only. For exact viscosity, pH, moisture content, ash content, particle size distribution, methoxyl content, hydroxypropoxyl content, and grade-specific values, please request the official TDS or COA from LANDERCOLL.

Karakterer
Gradvurdering

HPMC Product Grades —
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LANDERCOLL HPMC is available in multiple grade directions based on viscosity level, surface treatment, dissolution behavior, and target application. The information below is designed as a product selection reference. Final grade selection should always be confirmed through formulation testing and direct technical discussion with our team.

i.
Low Viscosity HPMC
Typically below 5,000 mPa·s
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ii.
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iii.
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iv.
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v.
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Hovedfunktioner

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HPMC in Formulation

HPMC is a multifunctional cellulose ether. In most applications, it contributes more than one functional benefit simultaneously. Below is a structured overview of its primary functions across different system types.

Tilbageholdelse af vand
i.
Tilbageholdelse af vand

In cement-based and gypsum-based systems, HPMC forms a polymer network that physically restricts water migration. Higher viscosity grades and higher dosage levels provide stronger water retention — preventing rapid water loss, incomplete hydration, and surface cracking.

Fortykkelse
ii.
Thickening & Viscosity Control

HPMC dissolves in cold water to form a viscous, pseudoplastic (shear-thinning) solution. Viscosity decreases under shear during mixing and recovers at rest — supporting both processability and in-place stability across drymix mortar, detergents, personal care, and coatings.

Arbejdsevne
iii.
Workability Improvement

In drymix construction materials, HPMC makes mortar smoother, more cohesive, and easier to spread, trowel, scrape, and finish. It is a combined result of water retention, viscosity building, and lubrication effects — particularly valued in tile adhesive, wall putty, and gypsum plaster.

iv.
Rheologikontrol

Supports flow control, sag resistance, leveling behavior, and application stability. Prevents mortar from sliding on vertical surfaces, contributes to controlled flow in self-leveling compounds, and maintains stable viscosity in coatings and detergents.

v.
Dannelse af film

HPMC forms a continuous, flexible film after water evaporation — used in pharmaceutical tablet coating, edible film systems, construction surface integrity, and selected water-based coatings as a binder component.

vi.
Binding, Cohesion & Suspension

Supports structural integrity in tablet manufacturing, green strength in ceramics, and cohesion in drymix mortar. Also helps maintain uniform suspension of pigments, fillers, mineral powders, and active ingredients in coatings, detergents, and pharmaceutical systems.

Anvendelsesguide

HPMC Application
Udvælgelsesguide

HPMC grade selection should always start from the application. A grade optimized for tile adhesive will not necessarily perform well in a detergent, personal care, or pharmaceutical system. The table below provides a structured reference for common application-to-grade matching.

AnvendelseAnbefalet klassificeringsretningHovedpræstationskrav
FliseklæberHigh to extra-high viscosityWater retention, open time, anti-slip, troweling feel
Spartelmasse til vægge / Skim CoatMedium to high viscositySmooth scraping, water retention, surface finish
Cementpuds / GipsMedium to high viscosityWorkability, spreadability, water retention
Gips PudsMedium to high viscositySmooth application, water management, consistency
Selvudjævnende forbindelserLow to medium viscosityFlow control, stability, controlled water retention
EIFS / ETICS MortarHøj viskositetOpen time, anti-sag, adhesion-related support
Vandtæt mørtelMedium to high viscosityWorkability, uniform coating, stable consistency
MurermørtelMedium to high viscosityWater retention, workability, bond support
ReparationsmørtelMedium to high viscosityAdhesion, workability, water retention
Flydende vaskemiddelMedium viskositetTexture, viscosity, storage stability
Personlig plejeLow to medium viscositySmooth texture, viscosity control, stability
Pharmaceutical ApplicationsSuitable pharmaceutical gradeFilm coating, binding, controlled release, excipient
Food ApplicationsSuitable food grade (E464)Thickening, stabilization, texture control
KeramikMedium to high viscosityBinding, green strength, suspension
Vandbaserede belægningerLow to medium viscosityThickening, film formation, particle suspension
Industrial AdhesivesMedium to high viscosityBinding, cohesion, process stability

Grade direction is a starting reference. Final selection should be confirmed through laboratory testing under your specific formulation conditions, water quality, temperature range, and application method.

Dosering Guide

HPMC Dosage Reference
efter Anvendelse

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Mortar application dosage
AnvendelseTypisk Reference Dosering (% efter vægt)
Fliseklæber0.2% – 0.5%
Spartelmasse til vægge / Skim Coat0.2% – 0.5%
Cementpuds / Gips0.15% – 0.4%
Gips Puds0.1% – 0.3%
Murermørtel0.1% – 0.3%
Selvudjævnende forbindelsercURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
EIFS / ETICS Mortar0.2% – 0.5%
Vandtæt mørtel0.15% – 0.4%
Reparationsmørtel0.15% – 0.4%
Flydende vaskemiddel0.2% – 1.0%
Personlig pleje0.1% – 1.0%
Vandbaserede belægninger0.1% – 0.8%
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Anvendelser

Konstruktion &Drymix-mørtel

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Fliseklæber

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  • Fliseklæber
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  • Gipspuds
  • Selvnivellerende forbindelser
  • EIFS / ETICS mørtel
  • Vandtæt mørtel
  • Murstensmørtel
  • Reparationsmørtel
  • Isoleringsmørtel
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Anvendelser

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Home care detergents Hjemmepleje & Rengøringsmidler

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& Detergent Formulations

As a non-ionic polymer, HPMC is compatible with anionic and non-ionic surfactant systems commonly used in cleaning products. It builds smooth, stable viscosity that improves product appearance, pourability, and consumer perception — while helping maintain uniform suspension of insoluble components.

Typiske Anvendelser

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  • Kontrolleret viskositet og produktkrop
  • Stable texture and appearance over shelf life
  • Improved pourability and handling feel
  • Suspension support for insoluble components
  • Compatible with common surfactant systems
Personal care products Personlig pleje

HPMC for Personal
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In personal care systems, HPMC functions as a viscosity modifier, texture enhancer, and formulation stabilizer. It is water-soluble, non-ionic, and free from animal-derived raw materials — making it suitable for a wide range of rinse-off and leave-on products where smooth, consistent texture and formulation stability across temperature and storage conditions are required.

Typiske Anvendelser

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  • Smooth, uniform texture and sensory feel
  • Controlled viscosity across temperature ranges
  • Stable formulation structure over shelf life
  • Non-ionic — does not interfere with charged ingredients
Farmaceutisk

HPMC for Pharmaceutical Applications

Suitable pharmaceutical grades of HPMC — referred to as Hypromellose in pharmacopoeial standards — are widely used as functional excipients in solid dosage forms, film coatings, and controlled-release systems. HPMC is recognized in the USP/NF, Ph. Eur., and JP pharmacopoeias.

Only grades manufactured and tested to pharmacopoeial standards should be used. Grade selection is based on viscosity grade, substitution type, regulatory compliance, and documentation requirements.

Typiske Anvendelser

  • Tablet binder (wet granulation & direct compression)
  • Film coating for immediate-release tablets
  • Matrix former for controlled-release tablets
  • HPMC capsule shell material (vegetarian alternative)
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  • Ophthalmic solutions & artificial tear formulations
  • Topical and semi-solid pharmaceutical systems

Farmaceutiske applikationer kræver passende kvalitetsvalg, farmakopeoverholdelse og relevant dokumentation. Kontakt LANDERCOLL for at drøfte tilgængeligheden af farmaceutisk kvalitet.

Discuss Pharma Grades
Food · E464

HPMC for Food Applications (E464)

Hydroxypropyl Methyl Cellulose is approved as a food additive under E464 in the European Union and is recognized in food regulations in many other markets. Suitable food-grade HPMC may be used as a thickener, stabilizer, emulsifier, film former, and texture modifier.

Food applications require HPMC grades meeting relevant food safety standards including purity specifications, heavy metal limits, and microbiological requirements. Compliance with the specific food regulations of the target market is required.

Typiske Anvendelser

  • Bakery products including gluten-free formulations
  • Sauces, dressings, and condiments
  • Frozen food systems (ice cream, frozen desserts)
  • Beverage systems
  • Edible film and coating applications
  • Vegetarian & vegan food products (gelatin alternative)
  • Thermal gelation: gels when heated, re-dissolves when cooled
  • Improved freeze-thaw stability
  • Suitable for vegetarian, vegan, and halal-compliant formulations

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Industrielle Anvendelser

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Industrial coatings application
Vandbaserede belægninger

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Teksturbelægninger

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Produktjämförelse

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Cellulose-ethere

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HPMC
Hydroxypropyl-methylcellulose
Ikke-ionisk

Versatile water retention, thickening, film forming, workability, broad application compatibility.

Byggeri · Pharma · Fødevarer · Personlig pleje · Rengøringsmidler · Industri
HEMC
Hydroxyethyl Methyl Cellulose (MHEC)
Ikke-ionisk

Strong construction performance, excellent water retention, good anti-sag in drymix mortar.

Tile adhesive · Wall putty · Cement plaster · Gypsum · EIFS/ETICS
HEC
Hydroxyethylcellulose
Ikke-ionisk

Excellent rheology control in aqueous systems, strong latex compatibility for coatings.

Water-based paints · Coatings · Cleaners · Personal care
CMC
Carboxymethylcellulose
Anionisk

Thickening, binding, stabilization, texture control; cost-effective across many systems.

Food · Detergents · Ceramics · Pharma · Oilfield · Paper

HPMC vs HEMC/MHEC for Construction

Both are non-ionic cellulose ethers for drymix construction materials and can deliver similar core functions. The choice depends on specific performance targets, regional market preferences, formulation system, and cost considerations. In many markets, HEMC/MHEC is preferred for high-performance tile adhesive and plaster due to its water retention profile. HPMC remains widely used globally across a broader range of industries.

HPMC vs HEC for Coatings

For water-based architectural coatings and latex paint systems, HEC is generally the preferred cellulose ether due to its strong compatibility with latex polymers and its well-established use in paint formulation. HPMC may be considered in specific coating systems, texture coatings, or where its film-forming or thermal gelation properties offer a formulation advantage.

Efter Branche

HPMC Grade Directions
Efter Branche

Construction grade
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Bygningsklasse

Designed for drymix construction materials requiring water retention, workability improvement, open time extension, anti-sag performance, and application consistency. Surface-treated grades commonly used.

Tile adhesive · Wall putty · Cement plaster · Gypsum plaster · Masonry mortar · Self-leveling · EIFS/ETICS · Waterproof mortar · Repair mortar · Insulation mortar
Detergent grade
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Vaskemiddelklasse

Designed for home care and cleaning systems where viscosity building, texture stability, product body, and storage stability are important. Compatible with common anionic and non-ionic surfactant systems.

Laundry liquid · Dishwashing liquid · Toilet cleaner · Surface cleaner · Gel cleaner
Personal care grade
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Personlig pleje-klasse

Designed for personal care products where smooth texture, stable viscosity, and user-friendly application feel are required. Non-ionic and compatible with a wide range of personal care actives.

Shampoo · Body wash · Facial cleanser · Lotion · Cream · Toothpaste · Styling products
Pharmaceutical grade
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Pharmaceutical Grade (Hypromellose)

Manufactured and tested to pharmacopoeial standards (USP/NF, Ph. Eur., JP). For pharmaceutical excipient applications where binding, coating, controlled release, or film performance may be required.

Tablet binder · Film coating · Controlled-release matrix · HPMC capsule shells · Oral film systems · Ophthalmic applications
Food grade E464
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Food Grade (E464)

Compliant with applicable food additive regulations. Designed for food systems where texture control, water management, stabilization, and formulation consistency are required.

Bakery products · Sauces & dressings · Frozen food · Edible films · Texture-modified food · Vegan & halal applications
Industrial grade
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Designed for specialty industrial systems requiring thickening, binding, suspension stability, and process control across various non-food, non-pharma applications.

Ceramics processing · Construction adhesives · Textile printing · Paper-related systems · Specialty industrial fluids
Logistik & Dokumentation

Emballage, Opbevaring & Tilgængelige dokumenter

Emballage & Opbevaring

Emballage og Opbevaring

LANDERCOLL HPMC is supplied in industrial packaging suitable for transportation, storage, and production handling. Cellulose ether powders are hygroscopic — proper storage conditions help maintain powder flowability, dissolution performance, and application effectiveness throughout product shelf life.

Standardemballage

  • 25 kg pr. pose
  • Papirpose med indvendig fugtbeskyttende polyethylenforing
  • Palleteret emballage tilgængelig efter anmodning
  • Customized packaging options can be discussed for long-term supply cooperation

Opbevaringsanbefalinger

  • Opbevar på et køligt, tørt og velventileret sted
  • Hold væk fra fugt, direkte sollys og varmekilder
  • Hold emballagen forseglet, når den ikke er i brug
  • Undgå forurening under håndtering og overførsel
  • Use within the recommended shelf life stated in product documentation
  • Opbevar ikke i nærheden af stærke oxidationsmidler eller reaktive kemikalier
Industrial packaging warehouse
Dokumentation

Produktdokumentation
Tilgængelig på anmodning

LANDERCOLL kan levere produktrelateret dokumentation til støtte for formuleringsevaluering, indkøbsrevision, teknisk kommunikation, regulatorisk indsendelse og interne godkendelsesprocesser.

Tilgængelige dokumenter

  • Teknisk datablad (TDS)
  • Sikkerhedsdatablad (SDS / MSDS)
  • Analyzecertifikat (COA)
  • Produktbrochure og anvendelsesvejledning
  • Anbefalingsdokument for kvalitet
  • Paknings- og opbevaringsspecifikation
  • Eksportrelateret dokumentation, hvor det er relevant

All documentation is provided to help customers complete their internal evaluation, purchasing approval, and regulatory review processes efficiently. Contact our team to request specific documents for your application or market requirements.

Anmod om produktdokumenter
Forespørgselsguide

Hvordan anmoder man om
Right HPMC Grade

To help our team recommend the most suitable HPMC grade for your application, please include as much of the following information as possible when contacting us. A detailed inquiry allows us to provide a more accurate grade recommendation and support your evaluation more efficiently.

i.
Application & Formulation System

Product application (e.g., tile adhesive, wall putty, shampoo, tablet coating) and formulation system type (cement-based, gypsum-based, liquid, semi-solid, other).

ii.
Current Grade or Viscosity Reference

Current HPMC grade or reference viscosity, if available. Main performance target — e.g., water retention, open time, viscosity level, texture, stability.

iii.
Testing Method & Quantity

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iv.
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OFTE STILLEDE SPØRGSMÅL

Ofte stillede spørgsmål
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What is the difference between surface-treated and non-surface-treated HPMC?

Surface-treated HPMC delays hydration when it contacts water, preventing premature lump formation and allowing the powder to disperse evenly before viscosity develops — commonly preferred in drymix mortar systems. Non-surface-treated HPMC dissolves more quickly and is preferred in systems where fast viscosity development is required.

Hvordan vælger jeg den rigtige HPMC-kvalitet?

The right HPMC grade depends on your application, required viscosity level, formulation system type (cement-based, gypsum-based, liquid, semi-solid), processing conditions, dissolution behavior requirement, and final performance targets. Contact LANDERCOLL with your application details, and our team can recommend suitable grade directions and support your formulation evaluation.

Can HPMC be used in multiple industries?

Yes. HPMC is one of the most versatile cellulose ethers, used across construction, home care, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors. Different industries require different grade selections — contact LANDERCOLL to identify the most suitable grade direction for your specific application and market.

Hvorfor LANDERCOLL

Hvorfor Vælge LANDERCOLL HPMC

i.

Fokuseret Ekspertise inden for Cellulose Ether

LANDERCOLL focuses on cellulose ether products — HPMC, HEMC/MHEC, HEC, and CMC. This product focus allows us to develop deeper application knowledge and provide more relevant technical support compared to general chemical distributors.

ii.

Application-Oriented Grade Matching

We help customers select HPMC based on real performance requirements — water retention, viscosity level, workability, open time, texture, stability, and processing behavior — rather than simply offering a product catalog.

iii.

Bred Industri Dækning

LANDERCOLL HPMC supports customers in construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial sectors across multiple global markets.

iv.

Teknisk Dokumentationsstøtte

We provide TDS, SDS, COA, product recommendation documents, and application guides to support your evaluation, purchasing review, and internal approval processes.

v.

Langsigtet Leveringspartnerskab

Vi sigter mod at støtte kunder fra den indledende produktforespørgsel gennem formuleringstest, indkøbsbeslutninger og langvarigt leveringssamarbejde — med konsekvent produktkvalitet og responsiv kommunikation.

Kontakt os

Find the Right HPMC Grade
for Din ansøgning

LANDERCOLL HPMC supports manufacturers across construction materials, detergents, personal care, pharmaceuticals, food, coatings, ceramics, and specialty industrial applications. Whether you are developing a new formulation, optimizing an existing product, or evaluating a new cellulose ether supplier, our team can help you identify the most suitable grade and provide the documentation and technical support you need.

~ Din forespørgsel · MMXXV ~
Produkt HPMC · CAS 9004-65-3
Anvendelse Din målformulering
Gradretning cURL Too many subrequests by single Worker invocation. To configure this limit, refer to https://developers.cloudflare.com/workers/wrangler/configuration/#limits
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Dokumenter TDS · SDS · COA
Marked Land & segment
Industrier Construction · Pharma · Food · Care